Pitfalls in Immunohistochemistry in Hematopathology: CD20 and CD3 Can Let Me Down?!
نویسنده
چکیده
The single most commonly used marker to identify B-cell lymphomas is CD20. Certain types of B-lineage lymphomas are characteristically negative for CD20, however. These include plasmablastic lymphoma, HHV8+ primary effusion lymphoma (and its extracavitary or solid variant), B lymphoblastic lymphoma/leukemia and ALK+ diffuse large B-cell lymphoma. On encountering one of these high grade lymphomas, the lack of CD20 may lead the pathologist to consider a diagnosis other than lymphoma. In addition, some CD20+ B-cell lymphomas in patients who have been treated with rituximab become CD20-negative.
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